U2AF1 and myelodysplastic syndrome: More than 90% of human genes could be affected by the splicing process which may lead to gene expression diversity.[4] Recurrent somatic mutations including splicing factor 3b, subunit 1 (SF3B1), serine/arginine-rich splicing factor 2 (SRSF2), U2 auxiliary factor protein 1 (U2AF1), and zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2 (ZRSR2) which are involved in the RNA splicing machinery have been identified in a considerable number of patients with MDS.[5]