For example, it was shown that ADC values might be associated with expression of vascular endothelial growth factor (VEGF) in several tumor entities, including prostate cancer,[16] thyroid nodules,[17] and rectal cancer.[18] VEGF is the most important factor to induce angiogenesis.[19] When ADC values are linked to VEGF expression, they might also be associated with MVD. This evidence concerns the gene VEGFA and rectal cancer.