Copy number variations (CNVs) are a kind of genetic variation that changes the dosage of some disease‐related genes by deletions, duplications, and insertions.13 It has been suggested to contribute substantially to the genetic risk of autoimmune diseases, including SLE.13, 14 Meanwhile, evidence suggests that the region of chromosome 6p21.1, where the HSP90AB1 gene is located is associated with SLE susceptibility.15 This study was to confirm the role of HSP90AB1 gene CNVs with the risk of SLE and efficacy of GCs. Here, HSP90AB1 is linked to autoimmune disease.