They play different roles in differentiation and development, as well as in response to heat stress and other environmental stimulations.10, 11 We have reported previously that genetic polymorphisms of HSP90AA1 had an influence on the response of SLE patients to GCs treatment.12 However, few prospective studies have examined the relationship between HSP90AB1 and GCs efficacy. Here, HSP90AA1 is linked to systemic lupus erythematosus.