Our earlier research showed that GR gene polymorphisms were associated with the improvement of HRQoL in SLE patients treated with glucocorticoids.18 Similar studies had found that HRQoL was associated with some genes including IL28B,34 BDNF,35 COMT36 and ADRB237 genes in different diseases. This evidence concerns the gene NR3C1 and systemic lupus erythematosus.