As shown in Table 3 and Figure 1, the HSP90AB1 gene CNVs were significantly associated with SLE (OR = 11.628, 95%CI = 1.496‐90.389, P = 0.019), and the association still existed after adjustment for age and sex (OR = 11.412, 95%CI = 1.467‐88.769, Padj = 0.020, PBH = 0.039). This evidence concerns the gene HSP90AB1 and systemic lupus erythematosus.