TARDBP and amyotrophic lateral sclerosis: ALS has been classified as a genetic disorder (involving mutations in superoxidedismutase 1 (SOD1) and TAR DNA-binding protein 43 (TDP-43) genes as well as the TAR/FUSbinding DNA factor and RNA proteins) only in 5–10% cases; however, the majority (90–95%) ofsubjects do not carry these genomic mutations and thus environmental factors responsible fordisease development must also be considered1,4, –6.