GALC and spinal cord injury: In vivo models showed that B cells and autoantibodies exacerbate tissue damage and impair neurological recovery after spinal cord injury.53, 54 Antibodies to galactocerebroside (GalC) and MOG can play a major role in destabilizing myelin through MBP breakdown.55 To date, most data indicate that B cell activation after a traumatic CNS injury, especially spinal cord injury (SCI), causes pathology leading to impaired recovery of neurological function.53, 54 In the current study, human MS patients have circulating antibodies specific for both human and mouse MOG.