In our study, overexpression of MST1 and knockdown of YAP could decrease the Bcl‐2/Bax ratio and other survival‐related proteins (c‐myc, survivin, cyclinD1, and CTGF) in NKTCL cells, thereby regulating the proliferation and apoptosis of NKTCL cells. This evidence concerns the gene CCN2 and extranodal nasal NK/T cell lymphoma.