In our study, overexpression of MST1 and knockdown of YAP could decrease the Bcl‐2/Bax ratio and other survival‐related proteins (c‐myc, survivin, cyclinD1, and CTGF) in NKTCL cells, thereby regulating the proliferation and apoptosis of NKTCL cells. The gene discussed is BIRC5; the disease is extranodal nasal NK/T cell lymphoma.