NF‐κB signaling pathway is extensively involved in the regulation of cell proliferation and development of multiple immune cells.7 Studies showed that NF‐κB was up‐regulated in the primary tumor cells of extranodal NKTCL caused by DDX3X (ATP‐dependent RNA helicase) mutation.8 These data proved that the continuous activation of the NF‐κB signaling pathway indicated potential carcinogenesis. Here, NFKB1 is linked to neoplasm.