PTK2 and ovarian cancer: PTK2 is located on chromosome 8q24.3 which had been linked to ovarian cancer susceptibility.30 It encodes focal adhesion kinase (FAK), which is a critical component in transmitting signals from extracellular environments into the cell, and its activation in cancer drives tumor progression and metastasis.31 Frequent PTK2 amplification had been reported in ovarian as well as other cancers,32, 33, 34 and was associated with poor overall survival.35 Recently, several FAK inhibitors have been developed and are being tested in clinical trials (NCT01138033, NCT01943292, and NCT00787033).