Among the four genes exceeding our threshold for eQTL and AMD GWAS colocalization, RDH5, encoding a retinol dehydrogenase that catalyzes the conversion of 11-cis retinol to 11-cis retinal in the visual cycle66, showed the most significant signal (Fig. 5a and Supplementary Data 11). This evidence concerns the gene RDH5 and age-related macular degeneration.