Relative abundance of M0 and M1 macrophages, neutrophils, activated mast cells, regulatory T cells (Treg), and T follicular helper (Tfh) cells, activated CD4+ memory T cells increased, while resting CD4+ memory T cells, mast cells, naive B cells, and resting dendritic cells decreased with tumor-promoting matrisomal change (Supplementary Data file S12). The gene discussed is CD4; the disease is neoplasm.