Intriguingly, TMI was highly negatively correlated with the gene set variation analysis (GSVA) z-scores of the responder signature for each breast cancer sample (TCGA BRCA; see Methods); higher levels of GSVA z-scores of the responder signature were found in TMIlow tumors, in which CIBERSORT-defined CD8+ T cell signatures were enriched in these selected tumors (Fig. 4d). Here, CD8A is linked to breast cancer.