Interestingly, in the case of CLN8, MRPL43, and MRPS4, our novel genes were co-expressed with a monogenic PD gene already implicated in mitochondrial function such as PARK7. Furthermore, with the exception of CLN8 (FASN, MPI, MRPL43 and MRPS3), the novel mitochondrial gene was assigned to a co-expression module enriched for neuronal markers (Supplementary Table 8). Here, CLN8 is linked to Parkinson disease.