MRPL43 and Parkinson disease: Furthermore, we note that a recent study that utilized whole exome sequencing (WES) data from two PD cohorts to investigate35,36 rare variation in nuclear genes associated with distinct mitochondrial processes, not only provided support for the involvement of mitochondrial function in sporadic PD, but also identified the gene, MRPL43, which encodes a component of the large mitochondrial ribosomal subunit.37 Interestingly, MRPL43 and MRPS34 were amongst five genes, which were also highly co-expressed in human brain with genes already known to cause monogenic forms of PD.