Although anti-Aspergillus azole prophylaxis has made a significant impact in reducing the rate of IMIs in the AML population, the increasing use of oral targeted therapies in AML (eg, FLT3 inhibitors, IDH inhibitors, venetoclax), as well as therapies that predispose patients to veno-occlusive disease (eg, gemtuzumab ozogamicin), has forced many clinicians to increase utilization of echinocandins for prophylaxis. Here, FLT3 is linked to hepatic veno-occlusive disease.