Functional immunity is comprised of two main conceptual components: (1) immune effector populations that act to regress the tumor including natural killer (NK) cells, N1 neutrophils, CD4+ helper T (Th) cells, CD8+ cytotoxic (CTL) T cells, M1 macrophages and mature dendritic cells (DC); and (2), immune suppressor cells that facilitate tumor escape, including N2 neutrophils, regulatory T (Treg) cells, myeloid-derived suppressor cells (MDSC), M2 macrophages, and tolerogenic DC [96]. The gene discussed is CD4; the disease is neoplasm.