A number of receptors expressed by prostate cancer cells mediating their spread to bone have been identified including chemokine receptor type four (CXCR4), chemokine receptor type seven (CXCR7), annexin II, integrin αvβ3, and Notch-Jagged [4]. As would be expected with such few cases reported, the mechanism of metastases of prostate cancer to the omentum has not been well described. One case report by Sheng et al. postulated port-site metastases after laparoscopic prostatectomy in a patient with peritoneal carcinomatosis [5]. Here, CXCR4 is linked to prostate cancer.