The effects of CK1α inactivation on the NF-ĸB pathway were analyzed in activated B cell-like diffuse large B-cell lymphoma (ABC-DLBCL)23, demonstrating that CK1α inactivation resulted in downregulation of the NF-ĸB pathway, activated downstream the B-cell receptor (BCR) signaling. Here, BCR is linked to diffuse large B-cell lymphoma.