CSNK1A1 and osteosarcoma: Since both normal17 and malignant5 PCs require autophagy for survival, CK1α regulates autophagy in RAS-driven cancer8 and CK1α downmodulation enhances the autophagic flux in osteosarcoma and neuroglioma cells10, we evaluated the effects of CK1α inactivation on autophagy in MM.