EMT/MET programs are regulated by a number of signalling pathways, e.g., TGFβ or WNT, and also by inflammatory stimuli, such as IL-6 in colorectal cancer5 and IL-6/IL-8 in breast cancer.6 Several transcription factors, such as those belonging to the ZEB, SNAIL and TWIST families, execute EMT programs in normal and pathological conditions. The gene discussed is TWIST1; the disease is breast cancer.