Reduction in S100A14 expression was also reported in A549 lung cancer cells undergoing an EMT in response to TGFβ1 treatment (GEO GSE17708) and S100A14 clustered with epithelial markers in breast cancer cells.23 In epithelial PDAC cells, S100A14 is localised to the cell–cell contacts indicating its potential role in maintenance of the epithelial morphology (Fig. 2a). Here, S100A14 is linked to breast cancer.