S100A4 and cancer: Their most frequently reported role is in the control of cell migration and invasion via direct interaction with cytoskeletal components.13,14 One of the S100 family members, S100A4 is considered as a biomarker of EMT in several cancer types including PDAC10,15 and has been proven to play a role in cancer metastasis.16 The association between EMT and other members of the S100 protein family in pancreatic cancer remains less clear.