S100A4 and cancer: Moreover, recent work has shown that S100A4 acts upstream of EMT-TFs in glioblastoma and is a master regulator of EMT-like events in this cancer type.33 Our study has shown that S100A4 and also S100A6, a family member displaying the highest homology with S100A4 (46% of identity and 59% of similarity), are indeed activated in the course of the ZEB1-induced EMT in PDAC cell lines.