Whereas deletion of Snai1 or Twist1 genes was dispensable for PDAC dissemination,7 knockout of Zeb1 strongly reduced invasion and metastases in this mouse strain.8 Particular importance of ZEB1 for PDAC dissemination is in line with the previous observation that its presence in primary tumours significantly correlates with shortened overall patient survival.9 Here, TWIST1 is linked to neoplasm.