Sunitinib (SU11248) was identified as a potent inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2) and beta-type platelet-derived growth factor receptor (PDGFRβ) that also inhibits KIT and FLT3 and therefore decreases cancer cell proliferation and survival, and blocks tumor angiogenesis. This evidence concerns the gene PDGFRB and neoplasm.