Numerous genes annotated to these putative enhancer regions e.g. CACNA1D, GLIS3, GRB10, HDAC9, HNF1B, INSIG2, PAX6, PDK4, SLC2A2 and TXNIP are known to be involved in T2D and islet function27,29–32. The gene discussed is HDAC9; the disease is type 2 diabetes mellitus.