Numerous genes annotated to these putative enhancer regions e.g. CACNA1D, GLIS3, GRB10, HDAC9, HNF1B, INSIG2, PAX6, PDK4, SLC2A2 and TXNIP are known to be involved in T2D and islet function27,29–32. The gene discussed is TXNIP; the disease is type 2 diabetes mellitus.