CTCF and type 2 diabetes mellitus: Intriguingly, motifs specific to key TFs in islets, including BORIS, BACH2, FOXO1, FOXA2, NEUROD1, MAFA and PDX1 as well as the motif for CTCF were significantly enriched in the ATAC-seq peaks with different prevalence in T2D islets (Supplemental Table 13).