We observed a significant increase in numbers of CD4+ T cells in PSP patients (t = 3.812, p < 0.001; Fig. 2B) accompanied by a shift in the ratio between memory and naive CD4+ T cells (t = 3.915, p < 0.001, and t = 7.940, p < 0.001, respectively; Fig. 2C,D). Here, CD4 is linked to supranuclear palsy, progressive, 1.