SLC1A2 and major depressive disorder: EAAT2 has been implicated in the pathophysiology of several disorders of the CNS, including Parkinson’s disease, epilepsy, amyotrophic lateral sclerosis, Alzheimer’s disease, addiction, schizophrenia, as well as MDD and BD.1 On the molecular level, there is strong evidence of downregulation of EAAT2 in diverse brain regions in MDD2,57.