NOTCH1 and gastric cancer: Besides, a former study also concluded that Notch1 silencing could reduce the anti-apoptotic protein Bcl-2, and increase the concentration of the pro-apoptotic protein Bax [48], while the current study observed that GC cells introduced with miR-140-5p inhibitor as well as si-Notch exhibited increased activated caspase-3, Bax and cleaved PARP1, along with decreased Bcl-2.