Consistent with previous reports, our study showed that the IC50 of each of the first-generation EGFR inhibitors was above 10 μΜ, and the inhibitory activity of AZD9291 on GBM cell growth was 10-fold higher than that of either of the first-generation EGFR inhibitors (Fig. 1b and c). The gene discussed is EGFR; the disease is glioblastoma.