When comparing between (ZAP-70+ CD38+) and (ZAP-70− CD38−), Hus et al. [26], Schroers et al. [16], D’arena et al. [27] found that there was significant correlation of (ZAP-70+ CD38+) with clinical presentation and hematological parameters while Gogia et al. [29] failed to find such associations in 80 B-CLL patients of whom 56% were concordant (ZAP-70+ CD38+). The gene discussed is CD38; the disease is B-cell chronic lymphocytic leukemia.