With the exception of Splenomegaly (P = 0.037), regarding age, sex, clinical findings, and hematological parameters means, there were no significant correlations between concordant ZAP-70 and CD38 expressions or with discordant expression of both (Tables 1, 2 and 3), same as Gogia et al. [29], Waheed et al. [28] reported, and in contrast to Hus et al. [26], Del Giudice et al. [25] who found that there were significant differences in the most hematological parameter between concordant groups. This evidence concerns the gene ZAP70 and Splenomegaly.