PFKFB3 and neoplasm: For example, PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3), an altered genes significantly accelerates the glycolysis, enhances the ability of DNA repair and its pro-tumor effects during glycolysis through the PFKFB3/Akt/ERCC1 signaling pathway, thus leading to failure of chemotherapy and radiotherapy in HCC [60].