Lastly, the AURKA/PLK1/FOXM1 axis inactivation is associated with a significant increase of GADD45a, a downstream target of AURKA central to CML acceleration towards blast crisis through events involving the dominant negative isoform of p30 C/EBPa, p38 and STAT5 [52]. Here, GADD45A is linked to chronic myelogenous leukemia, BCR-ABL1 positive.