CD274 and neoplasm: In RIPK3 knockout p48Cre;KrasG12D pancreases, the percentages of B cells and T cells were elevated, the percentages of peritumoral myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs), both of which can not only inhibit antitumor immune reactions but also stimulate tumor growth and metastasis [94, 95], were reduced and the expression of programmed death-ligand 1(PD-L1), a ligand which negatively regulates T cell antigen receptor signaling through interacting with its receptor PD-1 [96], in macrophages was decreased.