CD8A and neoplasm: Werthmöller et al. reported that the use of a combination of the pan-caspase inhibitor zVAD-fmk, which has been demonstrated to induce necroptosis, and other therapeutics, including radiotherapy, chemotherapy and hyperthermia, for the treatment of melanoma remarkably reduced tumor growth by reducing the tumor infiltration of regulatory T cells (Tregs) and increasing DC and CD8+ T-cell infiltration in the tumor microenvironment [24].