Additionally, despite evidence indicating that RIPK3 signaling may not play a role in the regulation of the activation of T lymphocytes, B lymphocytes and macrophages [84], RIPK3 has been suggested to regulate NKT cell function and promote the NKT cell- mediated anti-tumor immune response by activating mitochondrial phosphatase phosphoglycerate mutase 5 (PGAM5) through a process that is independent of the necroptosis pathway [85]. The gene discussed is PGAM5; the disease is neoplasm.