Staurosporine (STS), which is an alkaloid originally extracted from the bacterium Streptomyces staurosporeus [139, 140], has long been used in vitro to trigger apoptosis in many different cell types [106] and has been reported to induce RIPK1 and MLKL-dependent necroptotic cell death in leukemia cells when caspase activation is compromised [107]. The gene discussed is MLKL; the disease is leukemia.