A study conducted by Pietkiewicz et al. demonstrated that the combined treatment of CD95L and gemcitabine simultaneously induced apoptosis and necroptosis in pancreatic carcinoma cells and that gemcitabine significantly switched CD95- induced cell death into necroptosis when combined with CD95L in pancreatic carcinoma cells [146]. The gene discussed is FASLG; the disease is exocrine pancreatic carcinoma.