NFKB1 and neoplasm: Moreover, RIPK1 expression and NF-κB activation during programmed cell death are essential for initiating CD8+ T cell adaptive immunity, and RIPK3 has been suggested to regulate NKT cell function and promote the NKT cell-mediated anti-tumor immune response by activating mitochondrial phosphatase phosphoglycerate mutase 5 (PGAM5).