The study also demonstrated that resibufogenin may activate ﻿three key metabolic enzymes, including glycogen phosphorylase (PYGL), glutamine synthetase (GLUL), and glutamate dehydrogenase (GLUDl) in a RIPK3 dependent manner, and resibufogenin was also found to suppress liver metastasis of colorectal cancer in mouse models [110]. This evidence concerns the gene GLUL and colorectal cancer.