Studies performed on the Russian population have shown that five SNPs in OAS2 and OAS3 genes, as well as two SNPs in IFNL3/IL28B gene and SNPs in TLR3, CD209, IL10, MMP9, ABCB9, and COL22A1 genes were associated with predisposition to severe forms of TBE [36–41]. This evidence concerns the gene TLR3 and tick-borne encephalitis.