KLHL25 and tick-borne encephalitis: Combining several theoretical approaches (identification potentially pathogenic variants, identification of the variants, that were not common in non-Finnish Europeans, and identification of genetic variants, associated with severe forms of TBE), we detected eight new candidate genes (MAP4, WDFY4, ACTRT2, KLHL25, MAP2K3, MBD1, OR10J1, and OR2T34) that may be the most probable candidates affecting the cause of TBEV infection in the Russian population.