Among them were (1) 15 genes harboring the maximal number of the rare pathogenic variants in exomes of TBE patients (MSR1, LMO7, FLNA, PALLD, PKD1, VCAN, ANXA7, NEDD4, FLNC, NOD2, RTN4, COBL, CXCR1, GSR, and PIK3CD), and (2) five genes harboring genetic variants, associated with severe forms of TBE (WDFY4, ALK, MAP4, EPPK1, and BNIPL). Here, NOD2 is linked to tick-borne encephalitis.