After selecting and classifying these 15 studies, 3 were diabetic rat models with memory-impairment, 2 were 3 × Tg-AD mice models, 2 were Aβ infused rats models, 1 was an APP/PS1 mice model, 1 was a (Pilo)-induced epilepsy rat model, 1 was an ibotenic acid (ibo)-induced rat model and 5 memory-impairment models induced by Scopolamine, ICV-STZ, ethanol and D-galactose respectively. This evidence concerns the gene APP and Alzheimer disease.