In the subgroup analysis of the 10 most common AEs (diarrhea, fatigue, hypertension, nausea/vomiting, leukopenia, thrombocytopenia, neutropenia, increased creatinine, increased aspartate aminotransferase [AST], and increased alanine aminotransferase [ALT]), the outcomes of these grade 3–4 AEs indicated that there were no significant differences in hypertension, nausea/vomiting, and increased AST between the two groups. The gene discussed is GPT; the disease is hypertensive disorder.