For all grade AEs, sunitinib had higher incidences of fatigue (RR = 0.87, 95% CI: 0.79–0.96, P = 0.006), leukopenia (RR = 0.55, 95% CI: 0.50–0.61, P < 0.00001), thrombocytopenia (RR = 0.54, 95% CI: 0.48–0.60, P < 0.00001), neutropenia (RR = 0.54, 95% CI: 0.48–0.61, P < 0.00001), and increased creatinine (RR = 0.68, 95% CI: 0.59–0.79, P < 0.00001); pazopanib induced significantly higher rates of diarrhea (RR = 1.11, 95% CI: 1.01–1.23, P = 0.03) and increased ALT (RR = 1.35, 95% CI: 1.20–1.51, P <  0.00001, Table 2). This evidence concerns the gene GPT and Decreased total leukocyte count.