EIF4EBP1 and cancer: The DepMap [111, 112, 113] crispr (Avana) gene essentiality screens also predict 4EBP1 as a driver of cancer cell lines including all of the breast cancer cell line models currently represented within the portal (https://depmap.org/portal/) [94] Therefore, we performed experiments to validate the importance of 4EBP1 knockdown in SUM-44 cells and extended that to other breast cancer cell lines.