There is a consistently demonstrated occurrence between co-amplification of genomic loci harboring 4EBP1 (EIF4EBP1) and Cyclin D1 (CCND1) in breast cancer patients such as the recent report by Giltnane and colleagues [27], so further studies should assess how these two oncogenes together can influence cell cycle states, meiotic progression, and the regulation of aneuploidy. The gene discussed is EIF4EBP1; the disease is breast cancer.