After multivariable adjustment, increasing tertiles of serum OPG levels (β = 0.89 and 1.63 for tertile 2 and tertile 3, respectively, p for trend = 0.035) and the presence of DM (β = 1.83, p = 0.008) were the two independent factors that were associated with cfPWV values. The gene discussed is TNFRSF11B; the disease is diabetes mellitus.