We identified the downregulation of miR-9 in diabetic VSMCs by reference to the profile of diabetes-induced miRNA (17); based on a bioinformatic analysis (microRNA online predictive website microRNA.org), we presumed that KLF5 could be the target gene of miR-9 (mirSVR = –1.1778, PhastCons score = 0.5217) (Figure 1A). This evidence concerns the gene KLF5 and diabetes mellitus.