Also, nearly 14% of the annotated TM proteins were found to be neuronal related (Figure 3D) with respect to the GO database categories “cellular component” and ”molecular function”, e.g., reelin, centlein, neuron navigator 3, neuroblastoma amplified sequence, neurobeaching-like proteins (1, 2), neurochondrin, neurofascin, neuron navigator 1 and neurabin-2 (see Table S2). The gene discussed is NAV1; the disease is neuroblastoma.