PRKN and hepatocellular carcinoma: In addition, Hepatitis B virus X protein (HBx), a leading factor in Hepatitis B virus-related hepatocellular carcinoma, promotes PINK1-Parkin mediated mitophagy through the activation of the mitochondrial peptidase LON under starvation, which could be a determinant event in the development of hepatocellular carcinoma [237].