In particular, downregulation of PINK1/Parkin- or Rab9a-mediated mitophagy contributes to radiosensitizing cancer cells [297,298], and genetic downregulation of key mitophagy receptors such as PINK1, FUNDC1 or AMBRA1 also chemosensitizes cancer cells [170,299,300], supporting the pro-survival role of mitophagy in cancer cells in response to chemo/radiotherapy. This evidence concerns the gene PRKN and cancer.