Our recent study indicated that FAAH inhibition not only ameliorates microglial inflammation and pathological features including phosphorylated Tau protein in the TBI model one week post injury but also improves spatial learning and memory and synaptic integrity one month post injury [23], suggesting a possibility that Alzheimer’s disease induced by TBI can be prevented with FAAH inhibition. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.