We showed an imbalance in the metabolic synthesis of ω6-polyunsaturated fatty acids (PUFAs) in AD (FLG/WT) HEEs, which could be explained by a potential increase in the expression of several PLA2 isoforms (PLA2G2A, PLA2G2F, and PLA2G3). This evidence concerns the gene PLA2G2A and Alzheimer disease.