Alzheimer’s disease (AD) is an end-of-life neurodegenerative disease characterized by the presence of amyloid beta (Aβ) peptides (which collect to form senile plaques), as well as the formation and accumulation of hyperphosphorylated tau and neurofibrillary tangles (NFTs) in the brains of AD patients [1,2,3,4,5,6,7]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.