One study found that the women who had adiponectin rs2241766 (+45 T → G) TG genotype, the genotype associated with higher circulatory adiponectin, were at 39% lower risk of developing breast cancer where as those with adiponectin rs1501299 (+276 G → T) TG and GG genotypes, low adiponectin genotypes, were at 59% and 80% higher risk of developing breast cancer, respectively. Here, ADIPOQ is linked to breast cancer.