For example, NUMB/NUMBL that forms a negative feedback loop with Notch [92,93,94] can prevent a complete EMT, and consistent with that identification, knockdown of NUMB/NUMBL results in a mesenchymal phenotype and enables individual migration of the hybrid E/M NSCLC H1975 cells that typically migrate collectively [53]. The gene discussed is NUMBL; the disease is non-small cell lung carcinoma.