To identify whether cancer cells can acquire hybrid E/M phenotypes in vivo, Pastushenko et al. used fluorescence-activated cell sorting (FACS) to screen cell surface markers of skin squamous cell carcinoma (SCC) cells that can undergo spontaneous EMT and generate EpCAM+ epithelial cells and EpCAM− mesenchymal-like cells in genetically engineered mouse models [10]. The gene discussed is EPCAM; the disease is cancer.