IL17A and Hepatic fibrosis: Others demonstrated that CB2 receptor activation decreased liver fibrosis by selectively reducing interleukin 17 (IL-17) production of T-helper (Th)17 lymphocytes via a signal transducer and activator of transcription (STAT)5-dependent pathway, and by blunting the proinflammatory effects of IL-17 on its target cells, while preserving IL-22 production [182].