The expression of histone H3K18Ac acetylation, and proteins that regulate its acetylation (P300) and deacetylation (SIRT2), has been evaluated in benign prostatic hyperplasia (BPH), high grade prostatic intraepithelial neoplasia (HGPIN), prostate cancer (PCa), and metastases [107]. Here, SIRT2 is linked to Familial prostate cancer.