In light of the assessment of oxidative stress parameters in the liver tissues, including SOD, GSH-Px, GSH, and MDA, we confirmed that ZER exerts hepatoprotective effects against CCl4-induced ALI through reducing oxidative stress by recovering the activities of antioxidant enzymes, restoring the GSH reservoir, and reducing lipid peroxidation specifically. The gene discussed is SOD1; the disease is acute respiratory distress syndrome.