Feedforward models have been described previously for GR44 and other nuclear receptors.45, 46 It is worth noting that Jdp2 has been implicated in AP‐1 modulation during fear extinction,47 and polymorphisms in the Nos1ap gene have been linked to post‐traumatic stress disorder and depression,48 also demonstrating a functional role of these genes in the stress system. Here, JUN is linked to major depressive disorder.