The +37 kb enhancer is bound and activated by RUNX1, C/EBPα, GATA-2, SCL, NR4A1/3, PU.1, additional ETS family transcription factors, and potentially c-Myb in normal myeloid progenitors and is bound and potentially repressed by RUNX1-ETO in AML cases [13, 27, 28]. Here, RUNX1T1 is linked to acute myeloid leukemia.