HOXA9 gene expression has been found to be up-regulated in AML cases as a consequence of gene activation by MLL fusion proteins, NUP98 fusion proteins, CALM-AF10, NPM1c mutation, or decreased EZH2 or ASXL1, each often associated with intermediate- or high-risk cases [6]. The gene discussed is NUP98; the disease is acute myeloid leukemia.