NFKB1 and psoriasis: Given the facts that (1) the differentiation of keratinocytes is dependent on NF-κB signaling [25], (2) increased expression of NF-κB-dependent gene products is associated with skin inflammation and psoriasis [15, 26] and (3) the pleiotropic functions of NF-κB and cell-death signaling in various cell types that contribute to autoimmune and inflammatory diseases, it can be hypothesized that the dysregulation of NF-κB inhibitory signaling cascades may contribute to disease pathogenesis [16].