In capillaries from transgenic tauopathy model, upregulation for Sele, Selp, Chemokine (C-X-C Motif) Ligand 1 (Cxcl1), Plasminogen Activator (Plau), Natriuretic Peptide B (Nppb), Chemokine (C-C Motif) Ligand 2 (Ccl2), Matrix Metallopeptidase 9 (Mmp9), Serpin Peptidase Inhibitor 1 (Serpin 1), Tumor Necrosis Factor (Tnf), Prostaglandin-Endoperoxide Synthase 2 (Ptgs 2) was observed. The gene discussed is TNF; the disease is tauopathy.