On the other hand, in some specific exogenous bacterial or viral infection conditions, abnormal deposition of host DNA in cytosol can also activate the cGAS-cGAMP-STING signaling pathway cascade overwhelmingly, and it will result in uncontrolled over-inflammation, autoimmune diseases and immune cell draining [18], over-activation of STING contributes to even triggers the onset of autoimmune disorders such as systemic lupus erythematosus [19]. Here, CGAS is linked to autoimmune disease.