Moreover, the cells were found to be positive for CD20, BCL-2, BCL-6 and IRF-4 (Mum-1) and be negative for CD10 and CD5 by Immunofluorescence (Fig 4), which was similar to the immunophenotypic profiles of the majority of HBsAg-positive B-cell NHL patients (Table 2). This evidence concerns the gene IRF4 and B-cell non-Hodgkin lymphoma.