The phenotypes of CNP-KO [12] and activated fibroblast growth factor receptor 3 achondroplasia-phenotype (Fgfr3ach) mice [13] were similar to those in patients with achondroplasia, and the skull morphologies and narrow foramen magnum also resemble those in patients with achondroplasia [14]. The gene discussed is FGFR3; the disease is achondroplasia.