Numerous studies have confirmed the engagement of VGCCs in age‐related disease, including Parkinson disease (Cav1.3) (Zamponi et al., 2015), ataxia (Cav2.1) (Dorgans et al., 2017), Alzheimer's disease (Cav3.1) (Rice et al., 2014). The gene discussed is CACNA1G; the disease is early-onset autosomal dominant Alzheimer disease.