A recent study in melanoma suggests that suppressing JNK blocks PRDM5‐induced tumor progression.14 The JNK proteins (Jnk1, Jnk2, and Jnk3) are members of the mitogen‐activated protein kinase (MAPK) family and have been shown to exert controversial effects, acting either to mediate apoptosis or to sustain cell differentiation, proliferation, and tumorigenesis.15 Moreover, the JNK signaling pathway has been widely implicated in cancer migration and metastasis. The gene discussed is MAPK8; the disease is cancer.