JNK and p38 MAPK family members integrate signals that affect proliferation, differentiation, survival and migration in tumorigenesis.15 Increased JNK activation has been demonstrated in many studies of human cancers, including glioma, prostate carcinoma, osteosarcoma, and squamous cell carcinoma.27 The JNK pathway is a three‐tiered cascade. The gene discussed is MAPK8; the disease is osteosarcoma.